ADOLESCENT IDIOPATHIC SCOLIOSIS AND GENETICS

 

WHAT IS THE
SCOLISCORE TEST?

 

HOW THE SCOLISCORE
TEST WORKS

 

PATIENT RESOURCES

ScoliScore AIS Prognostic Test
Confidence in Patient Care
Reduced X-Ray Exposure
 

How The ScoliScore Test Works 

Sample collection for Adolescent Idiopathic Scoliosis (AIS) progression is quick, and can take place right in the physician's office. Your child will be asked to provide a saliva sample, which will then be sent for analysis at a lab. From your child's saliva, the lab will analyze their DNA for indicators associated with the likelihood for scoliosis progression. The ScoliScore Test has the ability to distinguish between patients who are likely to progress to a severe curve, and those who might not. The test performed on your child's saliva is strictly confidential, and only your child's physician will receive the results.

The ScoliScore Test uses specific DNA markers to predict the likelihood that an AIS curve will progress.

Did You Know
  • The current clinical factors used to predict the likelihood of curve progression to the point of requiring surgery (a combination of age, Cobb angle, Risser score, and x-ray results) are observational
  • Less predictive than the ScoliScore Test and knowledge of the initial curve angle
 

Researchers identified 28 signs in DNA that an AIS curve will progress (progressive genes), and 25 signs in DNA that an AIS curve will not progress (protective genes).

  • Children with AIS have both sets of signs in their DNA.
  • The ratio of signs present in a DNA sample predicts the likelihood that the child's curve will or won't progress.
  • A validated algorithm generates a ScoliScore number unique to your child's individual genetic markers. This score is provided to his/her physician in a test report.

The ability of The ScoliScore Test to predict whether a curve will progress has been demonstrated in clinical studies involving multiple samples of children with AIS.8

Additional Patient Resources
 
Progression
Markers, that when positive, contribute to progression of the curve.
Protective
Markers, that when positive, protect against progression of the curve.
Algorithm
set of rules for solving a problem in a finite number of steps, as for finding the greatest common divisor.
Source: www.dictionary.com
 
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